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KMID : 0378020060490090011
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New Medical Journal
2006 Volume.49 No. 9 p.11 ~ p.14
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Protective Effects of Seok-Jeong on CCl4-induced Hepatotoxicity in Rats
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Lee Jong-Wha
Hong Soon-Hai
Jang Bong-Ki
Park Jong-An
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Abstract
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Seok-Jeong is a solution of various metal ions and numerous other organic substances produced through extraction and fermentation of herbs and soil using geo-microbes, and it has been shown to improve symptoms of senile dementia. In this study, we investigated the protective effects of Seok-jeong (SJ) against hepatotoxicity of carbon tetrachloride in rat liver. In the light microscopic finding, fibrillation, infiltration of inflammatory cells and macrovacuolar granules were shown in rat liver treated by CCl4. Seok-Jeong significantly protected from the CCl4-induced hepatic injury. The protective effects of SJ against CCl4 toxicity were confirmed through observing lipid peroxidation formation. Additionally, SJ significantly decreased activities of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) which were increased by carbon tetrachloride. These results suggest that SJ may be a valuable agent for the protection of CCl4 toxicity in rat liver, and that the mechanism of the action of SJ may be due to reduced oxidative stress.
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KEYWORD
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Seok-Jeong, Carbon tetrachloride, Lipid peroxidation, Hepatotoxicity
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